A US military plane bringing several tonnes of much-needed baby formula from Germany landed Sunday (May 22) at an airport in Indiana as authorities scramble to address a critical shortage.

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Scarcity of medical-grade baby formula caused by production problems and supply-chain issues has created grave problems for thousands of parents whose infants, allergic to cow's milk protein, rely on it, sending them in frantic searches for the product.

The cargo plane took off from the US air base at Ramstein, Germany, carrying more than 70,000 pounds (31,750kg) of powdered formula, the White House said.

President Joe Biden posted about the flight on Twitter from Japan, where he is on a five-day Asia trip.

"Our team is working around the clock to get safe formula to everyone who needs it," he said.

The initial shipment will cover about 15 per cent of the immediate need, presidential economics advisor Brian Deese said on CNN.

He added there are "more flights in train that will be coming in early this week" as part of what the administration has dubbed "Operation Fly Formula".